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KMID : 0383419680090060751
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Korean Modern Medical Journal
1968 Volume.9 No. 6 p.751 ~ p.763
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Experimental Studies on Gastric Freezing
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Abstract
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Since Wangensteen and his associates introduced the technique of gastric freezing as an ulis, Histoge effective method for the treatment of peptic ulcer disease in 1962, many experimental and 13, 1952. clinical studies have been performed and conflicting results began to appear concerning the s, ain. North effectiveness of the technique. First of all, some observers claimed that the depression of gastric secretion was not always as impressive as Wangensteen had reported and they attriral Lesions, buted this to the possibility of patchiness of the freezing effect on the gastric mucosa which ´d. &Oral Path.. may also cause the known serious complications such as gastric hemorrhage, ulecerations 59 4 th Ed. 1954, or perforations. To improve the efficacy of the gastric freezing and to eliminate the compli-,ulis" Oral Surd cations, many modified techniques were attempted and some reported that the rapid rewarming following freezing showed more effective reduction of gastric acid secretion and 1953. decrease of the complications.
In view of these facts, the present study was designed to determine whether the more. ongenital Ep effective gastric freezing could be accomplished by repeated gastric freezings which may a´cover the patchiness of a single freezing and to compare the effectiveness of repeated freez Dent ings with and without rewarming.
All experimental dogs were given gastrotomies with stainless tubes at the most dependent portion of their stomaches for the gastric analysis which was performed every othe after each freeze, and then every week for five weeks.
For the preliminary test, 12 dogs were used to determine the minimal histamine do optimal gastric secretory responses by injecting histamine diphosphate in graded doses´ 4.02 mg/kg to 0.12mg/kg. The minimal histamine dose for the optimal gastric sec response in dogs was found to be 0.10 mg/kg. and at this_ dose the means of the voj` of gastric secretion, acidity and acid output were 80ml/hr., 100.0 mEq/L and 7.2 m respectively.
For the freezing experiment, 18 dogs were utilized and they were.divided into the foA: wing three groups:
Group I (control group): In this group of four dogs, gastric analysis was done wee without freezing or rewarming.
Group II: In this group of four dogs, a single freezing was accomplished with rapid rew arming in half of the,number (Group II-a) and without rewarming in the other hay (Group II-b).
Group III: In this group of 10 dogs, three successive gastric freezing with rewarming, e one week intervals, were done in 3 of the dogs (Group III-a), and without rewarming, the same one week intervals, in the other seven (Group III-b).
Gastric secretory and, histologic alterations as well as liver function and electrocardiograph " changes after or during the gastric freezing were observed and the results were summariz as follows:
1) There were a considerable variation and occasional rebound phenomena in the volume, acidity and hourly acid output and no dramatic reduction in all three modalities followin both a single and three successive gastric freezings. However, three successive freezings.´ produced more consistant and greater reduction in the volume and hourly acid output than a single freezing did. Rapid rewarming following freezing appeared to reduce the effects of freezing. There was no appreciable alteration of pH of gastric juice after freezing.
2) There were no significant histological and macroscopical changes in the stomach 6´ . weeks after the last gastric freezing.
3) There was no appreciable alteration in total protein, albumin, globulin,thymol turbidity test and alkaline phosphatase activity after gastric freezing, but BSP dye retention examined at the end of gastric freezing was eight times higher than control.
4) Electrocardiogram recorded during gastric freezing showed gradual bradycardia in 5550, prolongation of QRS and Q-T intervals, depression of ST segment and lowering or inversion 4 of T waves in 100%, and occasional ventricular extrasystoles.
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